The crowd is dense, with men in dark cloaks and women in lighter garments, some with shawls or head coverings, filling the open space from left to right. Behind the gathering rises the ornate façade of the Scuola Grande di San Rocco, its classical columns and arched windows festooned with garlands for the occasion. The church of San Rocco stands just to the right, its brick wall running vertically up the picture and forming a boundary to the scene.

Stretched above the crowd, pale awnings create a canopy, their fabric catching the sunlight and casting soft shadows below. The light is crisp and clear, illuminating the architecture and the figures while leaving deep shadows beneath the awnings and in the portico. The sky is a luminous blue, dotted with clouds that echo the cool tones of the buildings and the garments below.

The composition is carefully balanced, with the grand architecture forming a stable backdrop and the animated crowd providing rhythm and movement across the foreground. Several men in red robes stand in a line near the center, their garments creating a vivid diagonal accent through the crowd. A group of women wearing white shawls and bonnets gather at the lower left, some facing each other in conversation.

Bundles of goods and baskets are piled on the ground in the lower right corner, with a few figures bending over them. The sunlight strikes the upper façade of the Scuola, leaving the lower part and the church wall in deep shadow. The far left edge of the painting includes a cluster of men in black hats, some turning away from the viewer, emphasizing the crowd's density.

The paint handling is precise and linear, especially in the architectural details, with crisp outlines defining the windows, columns, and awnings. Venice: The Feast Day of Saint Roch was painted in 1735 by Giovanni Antonio Canal, known as Canaletto.