In John Henderson as Falstaff, the figure of John Henderson is depicted in rich, warm colors. He wears a lavish costume that reflects the character's jovial and larger-than-life persona. The background is relatively simple, allowing the viewer to focus on the expressive face and gestures of Henderson.

The overall composition conveys a sense of theatricality and charm. The painting is executed in oil on canvas, a common medium for portraits during the 18th century. The dimensions are approximately 76 x 63 cm, making it a sizable work that commands attention. The brushwork is detailed, particularly in the rendering of fabric and facial features, showcasing Romney's skill.

The use of color enhances the liveliness of the character portrayed. George Romney was a prominent British portrait painter known for his ability to capture the essence of his subjects. This painting, created in the 1760s, portrays John Henderson, a well-known actor of the time, as Falstaff, a character from Shakespeare's plays. An interesting fact about this work is that it reflects the growing popularity of Shakespearean theater in the 18th century.

Romney's portraits often blended realism with a romantic flair, making them highly sought after.