The Vision of Saint Jerome was painted by Parmigianino between 1526 and 1527, during his early maturity as an artist working in the Italian Renaissance. The painting is executed in oil on panel and is a significant example of the artist’s style at a time when he was active in Parma and Rome. This work is associated with the period when Parmigianino was developing his distinctive elongated forms and refined compositions. The composition is divided into two registers.

Above, the Madonna is seated on a cloud, holding the Christ Child, both with halos, surrounded by a luminous aura. The lower half features two male saints: a muscular, youthful Saint John the Baptist, clothed in a camel skin and pointing upward, and an aged Saint Jerome, asleep on the ground in a red drapery. The figures are rendered with smooth, idealized forms, and the use of light emphasizes the divine presence of the Madonna and Child, contrasting with the darker, earthier tones of the saints below. This painting is held in the collection of the National Gallery, London.

It was likely commissioned for a private chapel or church, reflecting the devotional practices of early 16th-century Italy. The Vision of Saint Jerome has been recognized as a key work in Parmigianino's oeuvre and has been exhibited as an example of the artist’s innovative approach to religious subjects during the High Renaissance.