Portrait of a Princess of the House of Este by Pisanello was painted between 1435 and 1440 in oil on a poplar panel. The work is a celebrated example of early Italian Renaissance portraiture and is generally associated with the courtly circles of Ferrara or Mantua, where Pisanello was active during this period. The sitter is traditionally identified as a young woman of the Este family, though her precise identity remains uncertain.

This painting is considered a key work in Pisanello's career, reflecting his skill in both portraiture and the depiction of natural elements. The panel presents a young woman in strict profile, set against a dark background filled with detailed botanical elements and butterflies. The sitter’s pale complexion and high forehead are accentuated by her tightly pulled-back hair, bound with white ribbons. Her elaborate dress features finely rendered textures, including pleated white fabric and puffed red sleeves, adorned with gold embroidery and a sprig of foliage.

The background is densely populated with various flowers and butterflies, painted with careful attention to naturalistic detail, contributing to the overall sense of refinement and delicacy. This portrait is widely recognized as one of the most important examples of profile portraiture in 15th-century Italy, a genre favored by the aristocratic courts of the time for its formality and emphasis on lineage. Works such as this were often commissioned to commemorate dynastic marriages or alliances. The painting is held in a major public collection today, where it continues to be studied for its technique, iconography, and its place within the tradition of Italian Renaissance portraiture.