Santa Trinita Maestà by Cimabue is a large tempera on panel altarpiece created between circa 1290 and circa 1300. The work depicts the Madonna and Child enthroned, surrounded by angels and, in the lower register, four prophets. This painting is a significant example of late 13th-century Florentine panel painting and is considered a key work in Cimabue's career, reflecting the transition from the Italo-Byzantine tradition to the early developments of naturalism in Italian art. The central figures are the Virgin Mary, seated on a monumental throne, and the Christ Child, both rendered with elongated proportions and solemn expressions.

Mary is enveloped in a dark blue mantle with gold highlights, while the Christ Child wears a red garment and raises his right hand in blessing. Angels flank the throne in symmetrical ranks, each with gilded halos and richly colored robes, holding architectural elements that emphasize the heavenly setting. The lower section features four Old Testament prophets, each identified by their scrolls, set within arched compartments beneath the throne.

The gold background and intricate punchwork create a luminous effect, characteristic of the period’s devotional art. The Santa Trinita Maestà was originally commissioned for the high altar of the church of Santa Trinita in Florence. Over the centuries, the altarpiece has been recognized as a milestone in the development of Florentine painting, admired for its scale and the dignity of its figures. It is now held in the Uffizi Gallery in Florence, where it remains an important object of study for the history of Italian art.

The work has been the subject of extensive scholarly attention and conservation efforts due to its historical and artistic significance.