Mary sits at the left, her head bowed and eyes lowered, holding the Christ Child on her lap. Mary’s robe is a deep green edged with gold embroidery, and beneath it she wears a vivid red garment, the folds rendered with soft, blended brushstrokes. The angel in the foreground wears a pinkish-red tunic with a golden collar and a white sleeve embroidered with black and gold designs.

Behind the figures, a stone wall and architectural setting frame the scene, with a blue sky visible through the openings at the sides. A garland of dark leaves and gold decorations arches above the group, suspended from the beams of the ceiling, adding a festive note to the composition. The light falls from the left, illuminating the faces and hands, and casting gentle shadows that model the forms in three dimensions.

The surface shows delicate transitions of color and careful layering of paint, especially in the rendering of flesh and fabric. The composition is tightly arranged, with the figures closely grouped and their gestures interlinked to create a sense of intimacy and tenderness. Two angels are positioned to the right of the Christ Child, one with curly hair and a golden halo, the other with auburn hair and a feathery dark wing visible at the edge of the composition.

The lower left corner features an elaborately carved golden chair decorated with red and black cushions and tassels. The halos above Mary and the angels are decorated with intricate gold patterns that catch the light and create a shimmering effect. The edges of the painting are bordered by architectural beams painted in muted tones of lavender and grey, framing the scene.

Fine, linear brushwork is visible in the delicate strands of hair and the embroidered patterns on the angels' sleeves and collars. Madonna and Child with Angels is created by Sandro Botticelli in the 15th century. The National Gallery of Art lists the work as part of the Samuel H. Kress Collection.