A young woman with a gentle, solemn expression stands at the center, holding a small child on her lap. She wears a blue mantle and a pink veil that frames her pale face, and her gaze meets the viewer directly. The child, unclothed except for a loosely draped pale blue cloth, twists his body and raises his right hand in a lively gesture, his eyes turned outward.

To the left, a figure with long, curling hair and a burgundy robe stands with one hand on his chest, his expression thoughtful as he looks toward the child. On the right, another youthful figure with wavy hair and a blue tunic trimmed in yellow holds an open book and gazes upward, his lips parted as if in mid-thought. Behind the central group, two large vases filled with blooming pink roses rise up, their foliage spreading across the background and framing the heads of the figures.

A slender cross, partially obscured by the roses, appears behind the child, adding a symbolic element to the composition. The figures are arranged in a tight, pyramidal group, their bodies overlapping and their gestures interlinked, creating a sense of intimacy and unity. Light falls softly from the left, illuminating the faces and hands, and casting gentle shadows that model the forms with subtle gradations.

The colours are clear and luminous, with deep blues, soft pinks, warm flesh tones, and touches of gold in the book and trim. The surface appears smooth and highly finished, with delicate transitions in the skin and fabrics, and precise, flowing lines defining the contours of the figures and flowers. A marble ledge in the foreground anchors the composition, its crisp lines contrasting with the softness of the drapery and skin.

A folded white cloth rests on the ledge beside the open book, rendered with careful attention to its folds and texture. The round format encloses the scene, focusing attention on the interaction between the four figures and the lush floral background. Madonna with Child, St. John the Baptist and Angel is created by Sandro Botticelli, as given in the catalogue.