Two women sit on either side of a carved stone trough, their bodies turned slightly toward each other but their gazes directed away, creating a sense of both connection and contrast. On the right, a nude woman drapes a vivid red mantle over her shoulder and sits with one leg crossed over the other, holding a dark vessel aloft in her raised hand while a white cloth loosely covers her lap. The light falls evenly across the scene, illuminating the pale skin of the nude figure and the lustrous folds of the clothed woman's dress, while the background recedes into cooler blues and greens.

Titian arranges the composition so that the two women, though differing in appearance, mirror each other in pose and facial features, suggesting a deliberate parallel. The brushwork is smooth and precise, especially in the rendering of fabrics and flesh, with subtle transitions of color and tone that create a sense of depth and atmosphere. Small details, such as the glint of metal on the vessels, the intricate embroidery on the dress, and the delicate leaves of the myrtle, reveal the artist's attention to texture and material.

A small winged child leans over the stone trough between the two women, reaching into the water with one hand while looking downward. In the left background, a cluster of buildings and a cylindrical tower rise among dark green trees, partially obscured by shadow. The sky is filled with soft clouds tinged with gold and blue, transitioning from light at the horizon to deeper blue at the top edge of the painting.

The lower right corner shows a patch of dark earth and scattered small stones, contrasting with the lush greenery elsewhere. The brushwork in the landscape is looser and more atmospheric, with visible strokes suggesting foliage and distant hills. Sacred and Profane Love is painted by Titian in the 1510s and is associated with the Venetian school and the High Renaissance movement.