Sir Kenelm Digby sits at the left, turned slightly toward his family, his right hand resting on his knee and his left arm draped over the armrest of a red chair beside a brass armillary sphere. He wears a richly embroidered gold doublet with a broad lace collar and a voluminous purple cloak, the folds of which catch the light and display van Dyck's fluid, confident brushwork. Lady Venetia Anastasia Stanley sits at his side, her body angled toward him but her gaze directed outward, her right hand gently encircling the shoulders of a young boy in a red suit.

Her dress is a deep blue satin with silver lace at the neckline and sleeves, and a large red plume adorns her hair, echoing the vividness of the boy's costume. Two boys stand close to their mother: the younger, in red with a white lace collar, looks out with parted lips, while the elder, dressed in white and gold, holds a golden drapery and gazes forward with a calm expression. The family is arranged before a monumental architectural background, with a heavy brown curtain drawn to the left and a sky filled with clouds and blue patches opening behind the group.

Light falls from the left, illuminating the faces and fabrics, heightening the sheen of satin and the intricate textures of lace and embroidery. The composition balances the seated figures and the children, creating a sense of unity through their interlinked gestures and the harmonious arrangement of color: gold, blue, red, and white. Anthony van Dyck paints the scene with smooth, blended strokes, especially in the faces and hands, while the fabrics reveal more vigorous, sweeping brushwork that suggests the play of light and texture.