Two young girls stand side by side, their figures filling the center of the composition, dressed in sumptuous gowns that catch the light with a soft sheen. The girl on the left wears a white satin dress adorned with a delicate lace shawl and a string of pearls around her neck, her hands gently clasped at her waist. Her companion, to the right, is dressed in a blue gown with voluminous sleeves, reaching out with both hands to adjust the other's sleeve in a gesture of affection and intimacy.

Both girls have pale, rounded faces framed by tight curls, and their expressions are calm and composed, their gazes directed outward. At their feet, a brown and white spaniel sits upright, one paw raised as if in greeting or supplication, its fur rendered with lively, textured brushwork. Behind the girls, a heavy green drapery falls in deep folds to the right, while to the left a stone wall opens onto a distant landscape with trees and a cloudy sky.

The light falls from the left, illuminating the faces and dresses of the girls, and casting soft shadows that give depth to the folds of their garments. The palette is dominated by the luminous whites and blues of the dresses, set off by the earthy browns of the dog and the muted green of the curtain. The brushwork is smooth and refined in the depiction of skin and fabric, while the background and the dog show looser, more textured strokes. The composition balances the figures against the architectural and natural elements, creating a sense of poised elegance and familial closeness.

Anthony van Dyck paints this double portrait in 1640, capturing Elizabeth Wharton and Philadelphia Wharton, as identified in the title.