Two figures stand against a stormy blue sky, each occupying one side of the canvas. On the left, a gaunt man with a wild beard and long hair is clothed in a rough garment of animal skin, his bare legs and feet exposed. He holds a slender reed cross in his left hand and points downward with his right, his gaze fixed on the other figure.

At his feet, a small lamb rests on the rocky ground, its head turned outward. To the right, a second man in a grey habit with a knotted rope belt stands barefoot, his right hand pressed to his chest and his left hand extended in a gentle gesture. His face is framed by a cowl, and his expression is solemn and contemplative as he looks toward his companion.

Light falls unevenly across the scene, highlighting the sharp contours of the bodies and the folds of the habit, while the background remains shadowy and turbulent. The palette is dominated by cool blues, greys, and earthy browns, with stark contrasts between flesh and fabric. Brushstrokes are visible in the sky and drapery, lending a sense of movement and texture to the surface.

The composition is tightly arranged, with both saints standing close together on a narrow strip of earth, their gestures forming a diagonal dialogue. Small details, such as the lamb’s curled body and the roughness of the rope belt, are rendered with careful attention. El Greco paints Saint John the Baptist and Saint Francis of Assisi at the turn of the 16th and 17th centuries, as noted by the Museu Nacional d'Art de Catalunya.