Three figures in sumptuous red and white garments cluster around a table covered in a deep red cloth. At the center sits a man in a papal robe and cap, his heavy features rendered with close attention to the folds of his flesh and the texture of his clothing. His hands rest on the table, one lightly gripping a magnifying glass and the other near an illuminated book, whose gilded edges and painted miniatures are visible.

A small, ornate silver bell with a red tassel sits beside the book, its surface gleaming as if recently polished. To the left, a cardinal in a red robe stands slightly behind, his head turned toward the central figure with a composed, attentive expression. On the right, another cardinal stands holding a chair topped with a golden orb, his gaze directed outward with a calm, steady look.

The background is dark, causing the vivid reds and intricate whites of the garments to stand out sharply against the shadow. Light falls from the left, illuminating the faces, the rich textures of the velvet and damask, and the gleaming surfaces of gold and silver. The brushwork is meticulously smooth, with delicate transitions of color and a remarkable illusion of depth and material.

Details such as the fur lining on the pope's sleeves and the reflective golden orb on the chair are rendered with striking realism. The composition forms a tight triangle, focusing attention on the central figure while connecting all three through their gestures and glances. Portrait of Leo X was created by Raphael in 1518.